COVID-19 Proteins

The SARS-CoV-2 virus, which is responsible for COVID-19, comprises nearly 30 proteins, including the Spike and Nucleocapsid proteins. RayBiotech offers a comprehensive catalog of recombinant SARS-CoV-2 proteins for all domains and variants of the COVID-19 virus. Other recombinant coronavirus proteins, including SARS-CoV, MERS-CoV, and HCoV-HKU1, are also available for purchase.

Browse All COVID-19 Proteins
SARS-CoV-2_Proteins

Features

The recombinant SARS-CoV-2 proteins recommended applications include ELISA, western blotting, lateral flow, antibody generation, vaccine development, and more. All recombinant proteins have a purity greater than 90% determined by SDS-PAGE under reducing conditions and visualized by Coomassie blue staining. Images are available on the product-specific pages. Multiple expression systems are available, including Human Embryonic Kidney 293 (HEK293) Cells and E.coli.

Learn about the roles SARS-CoV-2 proteins and endogenous proteins play in COVID-19 infection in our post “COVID-19 Biology 101”.

Types of COVID-19 Proteins

Spike Protein

The spike protein (S-protein) is a structural, transmembrane protein that is displayed on the surface of the viral particle.

Spike Protein Variants

SARS-CoV-2 variants have mutations within the gene encoding for the Spike (S) protein, which facilitates viral entry by binding to host receptors.

Nucleocapsid Protein

The nucleocapsid protein (N-protein) is a structural protein that binds to the coronavirus RNA genome.

Membrane Protein

The membrane protein (M-protein) is the most abundant structural protein of SARS-CoV-2.

Other Coronavirus Proteins

Recombinant SARS, MERS, and HKU1 coronavirus proteins.

Thrombosis Proteins

Inflammation associated with COVID-19 can lead to a type of thrombosis called "disseminated intravascular coagulopathy" (DIC).

Host Receptors

ACE2 is an endogenous receptor that is required for SARS-CoV-2 viral entry. Other host receptors, NRP1, AXL, CD147, GRP-78 also assist.

Browse All COVID-19 (SARS-CoV-2) Proteins

Nucleocapsid (N) Proteins:

Catalog # Protein Domain Expression Region Expression Host Tag
230-30164 Full length Met1 - Ala419 HEK293 Cell C-His
230-01104 Full length Met1 - Ala419 E.coli N-His

Spike Subunit 1 (S1) Proteins:

Catalog #Protein DomainExpression RegionExpression HostTag
230-30162RBDArg319 - Phe541HEK293 CellC-His
230-30166RBDArg319 - Phe541HEK293 CellC-Fc
230-01102RBDArg319 - Phe541E.coliN-His
230-30161Full lengthVal16 - Gln690HEK293 CellC-His
230-01101Full lengthVal16 - Gln690E.coliN-His
230-30191N-terminalVal16-Phe318HEK293 CellC-His
230-30214N-terminalVal16-Phe318HEK293 CellC-Fc

Spike Subunit 2 (S2) Proteins:

Catalog # Protein Domain Expression Region Expression Host Tag
230-01103Full lengthMet697 - Pro1213E.coliN-His
230-30163Full lengthMet697 - Pro1213HEK293 CellC-His
230-30179C-terminal CendR domainAsn542-Arg685HEK293 CellN-His
230-30180C-terminal CendR domainAsn542-Arg685HEK293 CellC-Fc

Membrane Proteins:

Catalog # Protein Domain Expression Region Expression Host Tag
230-01124Glycoprotein, C-terminalArg101-Gln222E.coliN-His

Variant Proteins:

Catalog # Protein Domain Subvariant Mutations Expression Host Tag
230-30157S1 RBDN331QHEK293 cellC-His
230-30184S1 RBDAlpha B.1.1.7 (U.K.), Beta B.1.351 (South Africa) Gamma P.1 (Brazil).N501YHEK293 cellC-His
230-30185S1 RBDAlpha B.1.1.7 (U.K.), Denmark Mink VariantY453F HEK293 cellC-His
230-30186S1 RBDAlpha B.1.1.7 (U.K.), Beta B.1.351 (South Africa)D614GHEK293 cellC-His
230-30187S1 RBDAlpha B.1.1.7 (U.K.)N439KHEK293 cellC-His
230-30188S1 RBDBeta B.1.351 (South Africa), Gamma P.1 (Brazil)E484KHEK293 cellC-His
230-30196S1 RBDDelta B.1.617.2 (India) L452R/E484Q HEK293 cellC-His
230-30197S1 RBDDelta B.1.617.2 (India) L452RHEK293 cellC-His
230-30198S1 RBDDelta B.1.617.2 (India) E484Q HEK293 cellC-His
230-30203S1 RBDDelta B.1.617.2 (India) T478KHEK293 cellC-His
230-30208S1 RBDDelta B.1.617.2 (India) L452R/T478KHEK293 cellC-His
230-30209S1 subunit, full lengthDelta B.1.617.2 (India) S1F, Y145HHEK293 cellC-His
230-30210S1 subunit, full lengthDelta B.1.617.2 (India) S1F, A222VHEK293 cellC-His
230-30211S1 subunit, full lengthDelta B.1.617.2 (India) S1F, Y145H/A222VHEK293 cellC-His
230-30206S1 RBDLambda C.37 (Peru) L452QHEK293 cellC-His
230-30207S1 RBDLambda C.37 (Peru) F490SHEK293 cellC-His
230-30202S1 RBDLambda C.37 (Peru) L452Q/F490SHEK293 cellC-His
230-30212S1 RBDMu B.1.621 (Colombia)R346KHEK293 cellC-His
230-30213S1 RBDMu B.1.621 (Colombia)R346K/E484K/N501YHEK293 cellC-His
230-30201S1 RBDOmicron B.1.1.529 (South Africa)G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505HHEK293 cellC-His
230-30218Nucleocapsid Protein Omicron B.1.1.529 (South Africa)P13L, E31del, R32del, S33del, R203K, G204RHEK293 cellC-His
230-30018S1 RBDOmicron B.1.1.529 BA.2 G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505HHEK293 cellC-His
230-30244S1 RBDOmicron BA.4 G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505HHEK293 cellC-His
230-30245S1 RBDOmicron BA.5 G339D, S371F, S373P, S375F, T376A, D405N, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505HHEK293 cellC-His
230-30246S1 RBDOmicron BA.2.75.2G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505HHEK293 cellC-His
230-30247S1 RBDOmicron XBB.1G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505HHEK293 cellC-His
230-30248S1 RBDOmicron BQ1.1 G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505HHEK293 cellC-His

Other SARS Proteins:

Catalog # Species Target Expression Host Tag
230-30192SARS CoVS1, full lengthHEK293 CellC-His
230-30193SARS CoVS1, RBD HEK293 CellC-His
230-30194SARS CoVNucleocapsid Protein HEK293 CellC-His
230-30195MERS CoVS1, full lengthHEK293 CellC-His
230-30204MERS CoVS1, RBD HEK293 CellC-His
230-30205MERS CoVNucleocapsid Protein HEK293 CellC-His
230-30199 HCov-HKU1S1, full lengthHEK293 CellC-His
230-30200 HCov-HKU1S1, RBD HEK293 CellC-His

S1 RBD Binding Proteins:

Catalog # Species Target Accesion # Expressed Region Expression Host Tag
230-30165 Human ACE2 Q9BYF1 Gln18 - Ser740 HEK293 Cell C-His
230-30177MouseACE2Q8R0I0Gln18-Thr740HEK293 Cell C-His
230-30176HumanNRP1, isoform 2O14786-2Phe22-Lys644HEK293 Cell C-His
230-30178HumanNRP1, isoform 1O14786-1Phe22-Pro856HEK293 Cell C-His
230-30189HumanNRP1, isoform 1
mutant (S346A, E348A, T349A) 		O14786-1Phe22-Pro856HEK293 Cell C-His
230-30100HumanGRP-78P11021Glu19-Leu654HEK293 Cell C-His
230-30181HumanBASIGIN, BSGP35613-2Thr28-Leu206HEK293 Cell C-His
230-30190HumanAXLP30530Ala26-Trp451HEK293 Cell C-His

Thrombosis-related Proteins:

Catalog # Species Target Accesion # Expressed Region Expression Host Tag
230-30170Coagulation factor II (F2), ThrombinHumanHEK293 CellP00734Full lengthN-His
230-30063SERPINE1MouseHEK293 CellQ7TPE9Full lengthN-His
230-30042SERPINF1MouseHEK293 CellP97298Full lengthN-His
230-30171Serpin F2HumanHEK293 CellP08697Asn40-Lys491N-His

Popular Recombinant SARS-CoV-2 Proteins

  1. Recombinant SARS-CoV-2, S1 Subunit Protein (RBD)
    Recombinant SARS-CoV-2, S1 Subunit Protein (RBD) Recombinant SARS-CoV-2, S1 Subunit Protein (RBD) with C-terminal His tag, derived from the transfected human HEK293 cells.
    Datasheet
  2. Recombinant SARS-CoV-2 Spike Protein, S1 Subunit
    Recombinant SARS-CoV-2 Spike Protein, S1 Subunit Recombinant SARS-CoV-2 Spike Protein, S1 Subunit derived from E.coli
  3. Recombinant SARS-CoV-2 S1 Subunit Protein (full length)
    Recombinant SARS-CoV-2 S1 Subunit Protein (full length)

    Recombinant SARS-CoV-2 S1 subunit protein with C-terminal His-tag, derived from the transfected human HEK293 cells.

  4. Recombinant SARS-CoV-2 Nucleocapsid Protein
    Recombinant SARS-CoV-2 Nucleocapsid Protein Recombinant SARS-CoV-2 Nucleocapsid Protein with C-terminal His-tag, derived from the transfected human HEK293 cells.
    Datasheet
  5. Recombinant SARS-CoV-2 Nucleocapsid Protein
    Recombinant SARS-CoV-2 Nucleocapsid Protein Recombinant SARS-CoV-2 Nucleocapsid Protein derived from E.coli
  6. Recombinant SARS-CoV-2 Spike Protein, S2 Subunit
    Recombinant SARS-CoV-2 Spike Protein, S2 Subunit Recombinant SARS-CoV-2 Spike Protein, S2 Subunit derived from E.coli

New Products

  1. Recombinant SARS-CoV-2 Omicron Variant B.1.1.529 Nucleocapsid (N) Protein
    Recombinant SARS-CoV-2 Omicron Variant B.1.1.529 Nucleocapsid (N) Protein Recombinant SARS-CoV-2 Omicron Variant B.1.1.529 Nucleocapsid (N), derived from the transfected human HEK293 cells.
  2. Recombinant SARS-CoV-2 Replicase Polyprotein 1a (3C-like Proteinase Nsp5)
    Recombinant SARS-CoV-2 Replicase Polyprotein 1a (3C-like Proteinase Nsp5) Recombinant SARS-CoV-2 replicase polyprotein 1a (3C-like Proteinase Nsp5) derived from E.coli
  3. Recombinant SARS-CoV-2 S1 Subunit Protein (RBD), mutant N331Q, Biotinylated
    Recombinant SARS-CoV-2 S1 Subunit Protein (RBD), mutant N331Q, Biotinylated Biotin-conjugated recombinant SARS-CoV-2 S1 subunit protein (RBD) mutant N331Q with C-terminal His-tag, derived from the transfected human HEK293 cells.
  4. Recombinant SARS-CoV-2 Nucleocapsid Protein, Biotinylated
    Recombinant SARS-CoV-2 Nucleocapsid Protein, Biotinylated Biotin-conjugated recombinant SARS-CoV-2 Nucleocapsid Protein with C-terminal His-tag, derived from the transfected human HEK293 cells.

What customers are saying

It works well for fluorescent labeling and confocal microscopy.

Research Scientist

University of California, Davis

We employed this protein for site-specific glycosylation analysis. It works great.

Research Scientist

University of California, Davis

viral-particle

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COVID-19 Pseudovirus Service

RayBiotech's COVID-19 pseudovirus service enables the study of the SARS-CoV-2 virus in cell culture. This service is ideal for screening patient serum for neutralizing antibodies, validating inhibitors of the Spike-ACE2 interaction, and COVID-19 vaccine development.

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