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IGF-1 Signaling Pathway
The insulin-like growth factor (IGF) signaling pathway functions in mediating cell proliferation, apoptosis, differentiation, survival, metabolism, and migration. These interactions provide a potent system that regulates many other processes such as cardiovascular, muscle, bone, and brain development. The IGF system comprises of IGF-1 and IGF-2 and their respective receptors, IGF-1 receptor and IGF-2 receptor, as well as six binding proteins, IGFBP1-6. The IGF signaling pathway has been implicated in aging, since it has important roles in many of the functions necessary for growth, metabolism and fertility. It has also been implicated in neurodegeneration, diabetes, and cancer progression.

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Schwartz S., Wongvipat J., Trigwell C., et al. Feedback Suppression of PI3Ka Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kb. Cancer Cell. 2015 Jan 12;27(1):109-22. doi: 10.1016/j.ccell.2014.11.008
Species: Human
Sample type: Conditioned Media (LNCaP cells treated with AZD8186)
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Del Fante, Claudia, et al. “Conditioned Medium Originated From Lethally Irradiated Umbilical Cord Blood-Derived Mononuclear Cells Has Different Pro-Angiogenic Effects Over Mature and Progenitor Endothelial Cells In Vitro.” (2013): 1068-1068.
Species: Human
Sample type: Conditioned Media (monnuclear cells)
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