RayPlex® Human Alzheimer’s Disease Magnetic Array 1

RayPlex is a multiplexed sandwich- and bead-based quantitative antibody array for the simultaneous detection of multiple proteins using small sample volumes. It couples the versatility of RayBiotech's vast antibody pair library with familiar, reliable flow cytometry methodology. Together this creates a multiplex bead- based array requiring no dedicated instrumentation, only common flow cytometers equipped with blue and red lasers.

RayPlex®-MagPro kits use magnetic beads. If preferred, an automatic plate washing system with magnetic separation ability can be used for washing steps. For data in this manual, a BioTek 405 TS Washer and LifeSep™ 96F magnetic separator unit were used. Further details are included in Section VI. Assay Protocol.

Alzheimer’s Disease is a neurodegenerative disease affecting one’s memory and cognitive function. The accumulation of beta-amyloid and phosphorylated Tau has been identified as having a strong correlation to the disease. This kit tests for two forms of phosphorylated Tau: pTau217 and pTau181. Both forms are associated with the early stages of disease. More research is necessary in order to confirm the mechanism that links these biomarkers and Alzheimer’s Disease, though, many researchers include the targets in their study of the disease and its progression.

• Less sample, more data: up to 25 proteins can be quantified from only 25 µl or less of your precious sample
• 4 hour processing time
• 5-10x more cost-effective than ELISA
• Compatible with most flow cytometers
• No specialized or dedicated instrument(s) needed
• High specificity and system reproducibility
• Well-suited for high throughput assays